top of page




a.   Development of a bismuth-213 labeled pyridyl benzofuran for targeted alpha therapy of amyloid beta aggregates            Bender, A. A.; Kirkeby, E. K.; Cross, D. J.; Minoshima, S.; Roberts, A. G.; Mastren, T. E.*

      submitted to J. Nucl. Med., January 2024

b.   Chemical cyclization of tyrosine-containing peptides via in situ generated triazolinedione peptides

      Keyes, E. D.; Mifflin, M. C.; Austin, M. J.; Sandres, J.; Roberts, A. G.*

      invited submission to Meth. Enzymol., submitted December 2023

      in Peptide and peptide mimicking tools: synthesis and methods (guest editor: David Chenoweth)

17. Lasso peptides: exploring the folding landscape of Nature’s smallest interlocked motifs

      da Hora, G. C. A.; Oh, M.; Mifflin, M. C.; Digal, L. D.; Roberts, A. G.; Swanson, J. S.*

      J. Am. Chem. Soc. 2024, online

      DOI: 10.1021/jacs.3c10126

      a) article previously on ChemRxiv:

16. Nonthreaded isomers of sungsanpin and ulleungdin lasso peptides inhibit H1299 cancer cell migration

      Digal, L. D.; Samson, S.; Stevens, M.; Ghorai, A.; Kim, H.; Mifflin, M. C.; Carney, K.; Williamson, D.;

      Um, S.; Nagy, G.; Oh, D.-C.; Mendoza, M. C.; Roberts, A. G.*

      ACS Chem. Biol., 2024, 19, 81.

      DOI: 10.1021/acschembio.3c00525

        (a) article previously on ChemRxiv:

15. A widespread methylotroph acyl-homoserine lactone synthase produces an atypical quorum sensing signal

      that regulates swarming in Methylobacterium fujisawaense

      Wallace, M.; Cummings, D. A.; Roberts, A. G.; Puri, A. W.*

      mBio, 2024, 15, e01999.

      DOI: 10.1128/mbio.01999-23

14. Deaminative ring contraction for the synthesis of polycyclic heteroaromatics:

      a concise total synthesis of toddaquinoline

      Kirkeby, E. K.; Schwartz, Z. T.;‡ Lovasz, M. A.;‡ Roberts, A. G.*

      Chem. Sci., 2023, 14, 10508.

      DOI: 10.1039/D3SC03936F

13. A promiscuous rSAM enzyme enables diverse peptide crosslinking

      Eastman, K.; Mifflin, M. C.; Oblad, P.; Roberts, A. G.; Bandarian, V.*

      ACS Bio. Med. Chem. Au, 2023, 3, 480. 

       DOI: 10.1021/acsbiomedchemau.3c00043

12. Recent applications of ammonium ylide based [2,3]-sigmatropic and [1,2]-Stevens rearrangements

      to transform amines into natural products

      Schwartz, Z.;‡ Valiton, C.;‡ Lovasz, M.;‡ Roberts, A. G.*

      Synthesis, 2023, 55, 87 – 106.

      DOI: 10.1055/s-0042-1751446

        (a) as part of the special topic, Advances in skeletal editing and rearrangement reactions

11. Chemoselective, oxidation-induced macrocyclization of tyrosine-containing peptides

      Keyes, E. D.; Mifflin, M. C.;  Austin, M. J.; Alvey, B. J.; Lovely, L. H.; Smith, A.; Rose, T. E.;

      Buck-Koehntop, B. A.; Motwani, J.; Roberts, A. G.*

      J. Am. Chem. Soc., 2023, 145, 10071.

      DOI: 10.1021/jacs.3c00210

        (a) selected as the editors' choice and highlighted here by Deirdre Lockwood:

        (b) highlighted in Synfacts by Trauner and Fialho, here:

        (c) article previously on ChemRxiv:

10. Design and evaluation of ambiphilic aryl thiol-iminium-based molecules for organocatalyzed thioacyl aminolysis

      Digal, L. D.; Kirkeby, E. K.; Austin, M. J.; Roberts, A. G.*

      ACS Omega, 2023, 8, 9319. 

      DOI: 10.1021/acsomega.2c07586

9.   Design and synthesis of astatinated benzothiazole compounds for their potential use in

      Targeted Alpha Therapy (TAT) strategies to treat Alzheimer’s disease-associated amyloid plaques

      Kirkeby, E. K.; Chyan, M.-K.; Diehl, G.; Wilbur, S.; Li, Y.; Roberts, A. G.;* Mastren, T.*

      Applied Radiation and Isotopes, 2023, 191, 110555.

      DOI: 10.1016/j.apradiso.2022.110555

8.   Establishing Self‐Dopant Design Principles from Structure–Function Relationships in

      Self‐n‐Doped Perylene Diimide Organic Semiconductors

      Powell, D.; Zhang, X.; Nwachukwu, C. I.; Miller, E. J.; Hansen, K. R.; Flannery, L.; Ogle, J.;

      Berzansky, A.; Labram, J. G.; Roberts, A. G.; Whittaker-Brooks, L.*

      Advanced Materials, 2022, 34, 2270292.

      DOI: 10.1002/adma.202270292

7.   Photoactivation Properties of Self-n-Doped Perylene Diimides:

      Concentration-dependent Radical Anion and Dianion Formation

      Powell, D.; Rhodes, Z.; Zhang, X.; Miller, E. J.; Jonely, M.; Hansen, K. R.; Nwachukwu, C. I.;

      Roberts, A. G.; Wang, H.; Noriega, R.; Minteer, S. D. Whittaker-Brooks, L.*

      ACS Materials Au, 2022, 2, 482.

      DOI: 10.1021/acsmaterialsau.2c00019

6.  An amine template strategy to construct successive C–C bonds:

     Synthesis of benzo[h]quinolines by a deaminative ring contraction cascade

     McFadden, T. P.; Nwachukwu, C. I.; Roberts, A. G.*

     Organic and Biomolecular Chemistry2022, 20, 1379.

     DOI: 10.1039/D1OB02245H

5.  Creating a natural vascular scaffold by photochemical treatment

     of the extracellular matrix for vascular applications

     Kauser, K.;* Warner, K. S.; Anderson, B.; Keyes, E. D.; Hayes, R. B.; Kawamoto, E.; Perkins, D. H.;

     Scott, R.; Isaacson, J.; Haberer, B.; Spaans, A.; Utecht, R.; Hauser, H.; Roberts, A. G.; Greenberg, M.

     International Journal of Molecular Sciences2022, 23, 683.

     DOI: 10.3390/ijms23020683

4New role for radical SAM enzymes in the biosynthesis of thio(seleno)oxazole RiPP natural products.

     Lewis, J. K.; Jochimsen, A. S.; Lefave, S. J.; Young, A. P.; Kincannon, W. M.;

     Roberts, A. G.; Kieber-Emmons, M. T.;  Bandarian, V.* 

     Biochemistry, 2021, 60, 3347 – 3361.

     DOI: 10.1021/acs.biochem.1c00469

3.  Photosensitized oxidative dimerization at tyrosine by a water-soluble 4-amino-1,8-naphthalimide.

     Keyes, E. D.; Kauser, K.; Warner, K. S.; Roberts, A. G.*

     ChemBioChem2021, 22, 2703 – 2710.

     DOI: 10.1002/cbic.202100193

2.  Design, synthesis, and characterization of structurally dynamic cyclic N,S-acetals.

     Kirkeby, E. K.; Roberts, A. G.*

     Chemical Communications2020, 56, 9118 – 9121.

     DOI: 10.1039/D0CC03503C
       (a) 2020 Emerging Investigators (link) (Chem. Commun., special issue)

       (b) Arora P and Brown G: Faculty Opinions Recommendation of [Kirkeby EK and Roberts AG, Chem Commun (Camb) 2020].

            In Faculty Opinions, 10 Aug 2020; 10.3410/f.738380854.793577286

1.  Ni-catalyzed iterative alkyl transfer from nitrogen enabled by the in situ methylation of tertiary amines.

     Nwachukwu, C. I.; McFadden, T. P.; Roberts, A. G.*

     Journal of Organic Chemistry2020, 85, 9979  9992.

     DOI: 10.1021/acs.joc.0c01274


mentored research.

6.  Cascading auto-oxidative biproline guanylations form optically active dispacamide dimers and permit an

     eight-step synthesis of (–)-ageliferin.

     Ding, H.; Roberts, A. G.; Chiang, R.; Harran, P. G.

     Journal of Organic Chemistry, 2018, 18, 7231 – 7238.

     DOI: 10.1021/acs.joc.8b00631

        (a) Synthesis of Antibiotics and Related Molecules (J. Org. Chem., Special Issue)

        (b) Synthesis of Antibiotics and Related Molecules (J. Org. Chem., Editorial)

             Movassaghi, M.; van der Donk, W. A. J. Org. Chem. 2018, 83, 6826.

5.  Total chemical synthesis and folding of all-L and all-D variants of oncogenic KRas(G12V).

     Levinson, A. M.‡; McGee, J. H.‡*; Roberts, A. G.‡*; Creech, G. S.; Wang, T.; Peterson, M. T.;                       

     Hendrickson,R. C.; Verdine, G. L.; Danishefsky, S. J.*   

     Journal of the American Chemical Society, 2017, 139, 7632 – 7639.   

     DOI: 10.1021/jacs.7b02988

        (a) highlight from Memorial Sloan Kettering Cancer Center

        (b) Tri-Institutional Program in Chemical Biology (TPCB) covers Dr. Levinson's thesis research!

        (c) Dr. Adam M. Levinson's PhD Thesis (2017)

4.  Fully synthetic granulocyte colony-stimulating factor (G-CSF) enabled by isonitrile-mediated coupling of

     large, side-chain unprotected peptides.

     Roberts, A. G.‡*; Johnston, E. V.‡; Shieh, J-H.; Sondey, J. P.; Hendrickson, R. C.;

     Moore, M. A. S.; Danishefsky, S. J.*

     Journal of the American Chemical Society, 2015, 137, 13167 – 13175.

     DOI: 10.1021/jacs.5b08754

        (a) F1000 Prime recommended article

        (b) highlight at Organic Chemistry Portal

3.  Total synthesis of ageliferin via acyl N-amidinyliminium ion rearrangement.

     Ding, H.‡; Roberts, A. G.‡; Harran, P. G.*

     Chemical Science,  2013, 4, 303 – 306.

     DOI: 10.1039/C2SC21651E


2.  Synthetic (±)-axinellamines deficient in halogen.

     Ding, H.; Roberts, A. G.; Harran, P. G.*

     Angewandte Chemie International Edition, 2012, 51, 4340 – 4343. (VIP paper)

     DOI: 10.1002/anie.201200205 

1.  Exploring symmetry-based logic for a synthesis of palau’amine.

     Li, Q.; Hurley, P.; Ding, H.; Roberts, A. G.; Akella, R.; Harran, P. G.*

     Journal of Organic Chemistry, 2009, 74, 5909 – 5919.

     DOI: 10.1021/jo900755r

     Ph.D. Thesis.

     Symmetry-based access to polycyclic bis-guanidines: total synthesis of (±)-ageliferin

     and the complete axinellamine ring system.

     by Roberts, A. G., Ph.D., University of California, Los Angeles, 2013, 1 – 482.

     UMI Number: 3592856 

* corresponding author ‡ equal contribution

ORCID / my NCBI / google / utah / bioscience / chemistry tree

bottom of page