02
publications.
19. Development of a bismuth-213 labeled pyridyl benzofuran for targeted alpha therapy of amyloid beta aggregates Bender, A. A.; Kirkeby, E. K.; Cross, D. J.; Minoshima, S.; Roberts, A. G.; Mastren, T. E.*
J. Nucl. Med., 2024, online
DOI: 10.2967/jnumed.124.267482
18. Chemical cyclization of tyrosine-containing peptides via in situ generated triazolinedione peptides
Keyes, E. D.; Mifflin, M. C.; Austin, M. J.; Sandres, J.; Roberts, A. G.*
Meth. Enzymol., 2024, 698, 89.
invited submission to in Peptide and peptide mimicking tools: synthesis and methods
(guest editor: David Chenoweth)
DOI: 10.1016/bs.mie.2024.04.019
17. Lasso peptides: exploring the folding landscape of Nature’s smallest interlocked motifs
da Hora, G. C. A.; Oh, M.; Mifflin, M. C.; Digal, L. D.; Roberts, A. G.; Swanson, J. S.*
J. Am. Chem. Soc. 2024, 146, 4444.
DOI: 10.1021/jacs.3c10126
a) article previously on ChemRxiv: https://chemrxiv.org/engage/chemrxiv/article-details/65020473b6ab98a41c6445b0
16. Nonthreaded isomers of sungsanpin and ulleungdin lasso peptides inhibit H1299 cancer cell migration
Digal, L. D.; Samson, S.; Stevens, M.; Ghorai, A.; Kim, H.; Mifflin, M. C.; Carney, K.; Williamson, D.;
Um, S.; Nagy, G.; Oh, D.-C.; Mendoza, M. C.; Roberts, A. G.*
ACS Chem. Biol., 2024, 19, 81.
DOI: 10.1021/acschembio.3c00525
(a) article previously on ChemRxiv: https://chemrxiv.org/engage/chemrxiv/article-details/64e4e239dd1a73847f4ef50b
15. A widespread methylotroph acyl-homoserine lactone synthase produces an atypical quorum sensing signal
that regulates swarming in Methylobacterium fujisawaense
Wallace, M.; Cummings, D. A.; Roberts, A. G.; Puri, A. W.*
mBio, 2024, 15, e01999.
14. Deaminative ring contraction for the synthesis of polycyclic heteroaromatics:
a concise total synthesis of toddaquinoline
Kirkeby, E. K.; Schwartz, Z. T.;‡ Lovasz, M. A.;‡ Roberts, A. G.*
Chem. Sci., 2023, 14, 10508.
13. A promiscuous rSAM enzyme enables diverse peptide crosslinking
Eastman, K.; Mifflin, M. C.; Oblad, P.; Roberts, A. G.; Bandarian, V.*
ACS Bio. Med. Chem. Au, 2023, 3, 480.
DOI: 10.1021/acsbiomedchemau.3c00043
12. Recent applications of ammonium ylide based [2,3]-sigmatropic and [1,2]-Stevens rearrangements
to transform amines into natural products
Schwartz, Z.;‡ Valiton, C.;‡ Lovasz, M.;‡ Roberts, A. G.*
Synthesis, 2023, 55, 87 – 106.
(a) as part of the special topic, Advances in skeletal editing and rearrangement reactions
11. Chemoselective, oxidation-induced macrocyclization of tyrosine-containing peptides
Keyes, E. D.; Mifflin, M. C.; Austin, M. J.; Alvey, B. J.; Lovely, L. H.; Smith, A.; Rose, T. E.;
Buck-Koehntop, B. A.; Motwani, J.; Roberts, A. G.*
J. Am. Chem. Soc., 2023, 145, 10071.
(a) selected as the editors' choice and highlighted here by Deirdre Lockwood: https://pubs.acs.org/doi/10.1021/jacs.3c04286
(b) highlighted in Synfacts by Trauner and Fialho, here: https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0042-1751932
10. Design and evaluation of ambiphilic aryl thiol-iminium-based molecules for organocatalyzed thioacyl aminolysis
Digal, L. D.;‡ Kirkeby, E. K.;‡ Austin, M. J.; Roberts, A. G.*
ACS Omega, 2023, 8, 9319.
9. Design and synthesis of astatinated benzothiazole compounds for their potential use in
Targeted Alpha Therapy (TAT) strategies to treat Alzheimer’s disease-associated amyloid plaques
Kirkeby, E. K.; Chyan, M.-K.; Diehl, G.; Wilbur, S.; Li, Y.; Roberts, A. G.;* Mastren, T.*
Applied Radiation and Isotopes, 2023, 191, 110555.
DOI: 10.1016/j.apradiso.2022.110555
8. Establishing Self‐Dopant Design Principles from Structure–Function Relationships in
Self‐n‐Doped Perylene Diimide Organic Semiconductors
Powell, D.; Zhang, X.; Nwachukwu, C. I.; Miller, E. J.; Hansen, K. R.; Flannery, L.; Ogle, J.;
Berzansky, A.; Labram, J. G.; Roberts, A. G.; Whittaker-Brooks, L.*
Advanced Materials, 2022, 34, 2270292.
7. Photoactivation Properties of Self-n-Doped Perylene Diimides:
Concentration-dependent Radical Anion and Dianion Formation
Powell, D.; Rhodes, Z.; Zhang, X.; Miller, E. J.; Jonely, M.; Hansen, K. R.; Nwachukwu, C. I.;
Roberts, A. G.; Wang, H.; Noriega, R.; Minteer, S. D. Whittaker-Brooks, L.*
ACS Materials Au, 2022, 2, 482.
DOI: 10.1021/acsmaterialsau.2c00019
6. An amine template strategy to construct successive C–C bonds:
Synthesis of benzo[h]quinolines by a deaminative ring contraction cascade
McFadden, T. P.; Nwachukwu, C. I.; Roberts, A. G.*
Organic and Biomolecular Chemistry, 2022, 20, 1379.
5. Creating a natural vascular scaffold by photochemical treatment
of the extracellular matrix for vascular applications
Kauser, K.;* Warner, K. S.; Anderson, B.; Keyes, E. D.; Hayes, R. B.; Kawamoto, E.; Perkins, D. H.;
Scott, R.; Isaacson, J.; Haberer, B.; Spaans, A.; Utecht, R.; Hauser, H.; Roberts, A. G.; Greenberg, M.
International Journal of Molecular Sciences, 2022, 23, 683.
4. New role for radical SAM enzymes in the biosynthesis of thio(seleno)oxazole RiPP natural products.
Lewis, J. K.; Jochimsen, A. S.; Lefave, S. J.; Young, A. P.; Kincannon, W. M.;
Roberts, A. G.; Kieber-Emmons, M. T.; Bandarian, V.*
Biochemistry, 2021, 60, 3347 – 3361.
DOI: 10.1021/acs.biochem.1c00469
3. Photosensitized oxidative dimerization at tyrosine by a water-soluble 4-amino-1,8-naphthalimide.
Keyes, E. D.; Kauser, K.; Warner, K. S.; Roberts, A. G.*
ChemBioChem, 2021, 22, 2703 – 2710.
2. Design, synthesis, and characterization of structurally dynamic cyclic N,S-acetals.
Kirkeby, E. K.; Roberts, A. G.*
Chemical Communications, 2020, 56, 9118 – 9121.
DOI: 10.1039/D0CC03503C
(a) 2020 Emerging Investigators (link) (Chem. Commun., special issue)
(b) Arora P and Brown G: Faculty Opinions Recommendation of [Kirkeby EK and Roberts AG, Chem Commun (Camb) 2020].
In Faculty Opinions, 10 Aug 2020; 10.3410/f.738380854.793577286
1. Ni-catalyzed iterative alkyl transfer from nitrogen enabled by the in situ methylation of tertiary amines.
Nwachukwu, C. I.; McFadden, T. P.; Roberts, A. G.*
Journal of Organic Chemistry, 2020, 85, 9979 – 9992.
mentored research.
eight-step synthesis of (–)-ageliferin.
Ding, H.; Roberts, A. G.; Chiang, R.; Harran, P. G.
Journal of Organic Chemistry, 2018, 18, 7231 – 7238.
(a) Synthesis of Antibiotics and Related Molecules (J. Org. Chem., Special Issue)
(b) Synthesis of Antibiotics and Related Molecules (J. Org. Chem., Editorial)
Movassaghi, M.; van der Donk, W. A. J. Org. Chem. 2018, 83, 6826.
5. Total chemical synthesis and folding of all-L and all-D variants of oncogenic KRas(G12V).
Levinson, A. M.‡; McGee, J. H.‡*; Roberts, A. G.‡*; Creech, G. S.; Wang, T.; Peterson, M. T.;
Hendrickson,R. C.; Verdine, G. L.; Danishefsky, S. J.*
Journal of the American Chemical Society, 2017, 139, 7632 – 7639.
DOI: 10.1021/jacs.7b02988
(a) highlight from Memorial Sloan Kettering Cancer Center
(b) Tri-Institutional Program in Chemical Biology (TPCB) covers Dr. Levinson's thesis research!
(c) Dr. Adam M. Levinson's PhD Thesis (2017)
4. Fully synthetic granulocyte colony-stimulating factor (G-CSF) enabled by isonitrile-mediated coupling of
large, side-chain unprotected peptides.
Roberts, A. G.‡*; Johnston, E. V.‡; Shieh, J-H.; Sondey, J. P.; Hendrickson, R. C.;
Moore, M. A. S.; Danishefsky, S. J.*
Journal of the American Chemical Society, 2015, 137, 13167 – 13175.
DOI: 10.1021/jacs.5b08754
(a) F1000 Prime recommended article
(b) highlight at Organic Chemistry Portal
3. Total synthesis of ageliferin via acyl N-amidinyliminium ion rearrangement.
Ding, H.‡; Roberts, A. G.‡; Harran, P. G.*
Chemical Science, 2013, 4, 303 – 306.
DOI: 10.1039/C2SC21651E
2. Synthetic (±)-axinellamines deficient in halogen.
Ding, H.; Roberts, A. G.; Harran, P. G.*
Angewandte Chemie International Edition, 2012, 51, 4340 – 4343. (VIP paper)
1. Exploring symmetry-based logic for a synthesis of palau’amine.
Li, Q.; Hurley, P.; Ding, H.; Roberts, A. G.; Akella, R.; Harran, P. G.*
Journal of Organic Chemistry, 2009, 74, 5909 – 5919.
DOI: 10.1021/jo900755r
Symmetry-based access to polycyclic bis-guanidines: total synthesis of (±)-ageliferin
and the complete axinellamine ring system.
by Roberts, A. G., Ph.D., University of California, Los Angeles, 2013, 1 – 482.
* corresponding author ‡ equal contribution
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