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20. Deaminative ring contraction for the synthesis of polycyclic heteroaromatics:

      a concise total synthesis of toddaquinoline

      Kirkeby, E. K.; Schwartz, Z. T.;‡ Lovasz, M. A.;‡ Roberts, A. G.*

      Chem. Sci., 2023advance article

      DOI: 10.1039/D3SC03936F

19. A promiscuous rSAM enzyme enables diverse peptide crosslinking

      Eastman, K.; Mifflin, M. C.; Oblad, P.; Roberts, A. G.; Bandarian, V.*

      ACS Bio. Med. Chem. Au, 2023, 

       DOI: 10.1021/acsbiomedchemau.3c00043

18. Recent applications of ammonium ylide based [2,3]-sigmatropic and [1,2]-Stevens rearrangements

      to transform amines into natural products

      Schwartz, Z.;‡ Valiton, C.;‡ Lovasz, M.;‡ Roberts, A. G.*

      Synthesis, 2023, 55, A – T.

      DOI: 10.1055/s-0042-1751446

        (a) as part of the special topic, Advances in skeletal editing and rearrangement reactions

17Chemoselective, oxidation-induced macrocyclization of tyrosine-containing peptides

      Keyes, E. D.; Mifflin, M. C.;  Austin, M. J.; Alvey, B. J.; Lovely, L. H.; Smith, A.; Rose, T. E.;

      Buck-Koehntop, B. A.; Motwani, J.; Roberts, A. G.*

      J. Am. Chem. Soc., 2023, 145, 10071.

      DOI: 10.1021/jacs.3c00210

        (a) selected as the editor’s choice and highlighted here:

        (b) previously at:

16. Design and evaluation of ambiphilic aryl thiol-iminium-based molecules for organocatalyzed thioacyl aminolysis

      Digal, L. D.; Kirkeby, E. K.; Austin, M. J.; Roberts, A. G.*

      ACS Omega, 2023, 8, 9319. 

      DOI: 10.1021/acsomega.2c07586

15. Design and synthesis of astatinated benzothiazole compounds for their potential use in

      Targeted Alpha Therapy (TAT) strategies to treat Alzheimer’s disease-associated amyloid plaques

      Kirkeby, E. K.; Chyan, M.-K.; Diehl, G.; Wilbur, S.; Li, Y.; Roberts, A. G.;* Mastren, T.*

      Applied Radiation and Isotopes, 2023, 191, 110555.

      DOI: 10.1016/j.apradiso.2022.110555

14. Establishing Self‐Dopant Design Principles from Structure–Function Relationships in

      Self‐n‐Doped Perylene Diimide Organic Semiconductors

      Powell, D.; Zhang, X.; Nwachukwu, C. I.; Miller, E. J.; Hansen, K. R.; Flannery, L.; Ogle, J.;

      Berzansky, A.; Labram, J. G.; Roberts, A. G.; Whittaker-Brooks, L.*

      Advanced Materials, 2022, 34, 2270292.

      DOI: 10.1002/adma.202270292

13. Photoactivation Properties of Self-n-Doped Perylene Diimides:

      Concentration-dependent Radical Anion and Dianion Formation

      Powell, D.; Rhodes, Z.; Zhang, X.; Miller, E. J.; Jonely, M.; Hansen, K. R.; Nwachukwu, C. I.;

      Roberts, A. G.; Wang, H.; Noriega, R.; Minteer, S. D. Whittaker-Brooks, L.*

      ACS Materials Au, 2022, 2, 482.

      DOI: 10.1021/acsmaterialsau.2c00019

12. An amine template strategy to construct successive C–C bonds:

      Synthesis of benzo[h]quinolines by a deaminative ring contraction cascade

      McFadden, T. P.; Nwachukwu, C. I.; Roberts, A. G.*

      Organic and Biomolecular Chemistry2022, 20, 1379.

      DOI: 10.1039/D1OB02245H

11. Creating a Natural Vascular Scaffold by Photochemical Treatment

      of the Extracellular Matrix for Vascular Applications

      Kauser, K.;* Warner, K. S.; Anderson, B.; Keyes, E. D.; Hayes, R. B.; Kawamoto, E.; Perkins, D. H.;

      Scott, R.; Isaacson, J.; Haberer, B.; Spaans, A.; Utecht, R.; Hauser, H.; Roberts, A. G.; Greenberg, M.

      International Journal of Molecular Sciences2022, 23, 683.

      DOI: 10.3390/ijms23020683

10. New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products.

      Lewis, J. K.; Jochimsen, A. S.; Lefave, S. J.; Young, A. P.; Kincannon, W. M.;

      Roberts, A. G.; Kieber-Emmons, M. T.;  Bandarian, V.* 

      Biochemistry, 2021, 60, 3347 – 3361.

      DOI: 10.1021/acs.biochem.1c00469

9.  Photosensitized Oxidative Dimerization at Tyrosine by a Water-Soluble 4-amino-1,8-naphthalimide.

     Keyes, E. D.; Kauser, K.; Warner, K. S.; Roberts, A. G.*

     ChemBioChem2021, 22, 2703 – 2710.

     DOI: 10.1002/cbic.202100193

8.  Design, synthesis and characterization of structurally dynamic cyclic N,S-acetals.

     Kirkeby, E. K.; Roberts, A. G.*

     Chemical Communications2020, 56, 9118 – 9121.

     DOI: 10.1039/D0CC03503C
       (a) 2020 Emerging Investigators (link) (Chem. Commun., special issue)

       (b) Arora P and Brown G: Faculty Opinions Recommendation of [Kirkeby EK and Roberts AG, Chem Commun (Camb) 2020].

            In Faculty Opinions, 10 Aug 2020; 10.3410/f.738380854.793577286


7.  Ni-catalyzed iterative alkyl transfer from nitrogen enabled by the in situ methylation of tertiary amines.

     Nwachukwu, C. I.; McFadden, T. P.; Roberts, A. G.*

     Journal of Organic Chemistry2020, 85, 9979  9992.

     DOI: 10.1021/acs.joc.0c01274


mentored research.

6.  Cascading auto-oxidative biproline guanylations form optically active dispacamide dimers and permit an

     eight-step synthesis of (–)-ageliferin.

     Ding, H.; Roberts, A. G.; Chiang, R.; Harran, P. G.

     Journal of Organic Chemistry, 2018, 18, 7231 – 7238.

     DOI: 10.1021/acs.joc.8b00631

        (a) Synthesis of Antibiotics and Related Molecules (J. Org. Chem., Special Issue)

        (b) Synthesis of Antibiotics and Related Molecules (J. Org. Chem., Editorial)

             Movassaghi, M.; van der Donk, W. A. J. Org. Chem. 2018, 83, 6826.

5.  Total Chemical Synthesis and Folding of all-L and all-D Variants of Oncogenic KRas(G12V).

     Levinson, A. M.‡; McGee, J. H.‡*; Roberts, A. G.‡*; Creech, G. S.; Wang, T.; Peterson, M. T.;                       

     Hendrickson,R. C.; Verdine, G. L.; Danishefsky, S. J.*   

     Journal of the American Chemical Society, 2017, 139, 7632 – 7639.   

     DOI: 10.1021/jacs.7b02988

        (a) highlight from Memorial Sloan Kettering Cancer Center

        (b) Tri-Institutional Program in Chemical Biology (TPCB) covers Dr. Levinson's thesis research!

        (c) Dr. Adam M. Levinson's PhD Thesis (2017)

4.  Fully Synthetic Granulocyte Colony-Stimulating Factor (G-CSF) Enabled by Isonitrile-Mediated Coupling of Large,           Side-Chain Unprotected Peptides.

     Roberts, A. G.‡*; Johnston, E. V.‡; Shieh, J-H.; Sondey, J. P.; Hendrickson, R. C.;

     Moore, M. A. S.; Danishefsky, S. J.*

     Journal of the American Chemical Society, 2015, 137, 13167 – 13175.

     DOI: 10.1021/jacs.5b08754

        (a) F1000 Prime recommended article

        (b) highlight at Organic Chemistry Portal

3.  Total Synthesis of Ageliferin via Acyl N-amidinyliminium Ion Rearrangement.

     Ding, H.‡; Roberts, A. G.‡; Harran, P. G.*

     Chemical Science,  2013, 4, 303 – 306.

     DOI: 10.1039/C2SC21651E


2.  Synthetic (±)-Axinellamines Deficient in Halogen.

     Ding, H.; Roberts, A. G.; Harran, P. G.*

     Angewandte Chemie International Edition, 2012, 51, 4340 – 4343. (VIP paper)

     DOI: 10.1002/anie.201200205 

1.  Exploring Symmetry-Based Logic for a Synthesis of Palau’amine.

     Li, Q.; Hurley, P.; Ding, H.; Roberts, A. G.; Akella, R.; Harran, P. G.*

     Journal of Organic Chemistry, 2009, 74, 5909 – 5919.

     DOI: 10.1021/jo900755r

    Ph.D. Thesis.

    Symmetry-Based Access to Polycyclic Bis-guanidines: Total Synthesis of (±)-Ageliferin

    and the Complete Axinellamine Ring System.

    by Roberts, A. G., Ph.D., University of California, Los Angeles, 2013, 1 – 482.

    UMI Number: 3592856 

* corresponding author ‡ equal contribution

ORCID / my NCBI / google / utah / bioscience / chemistry tree

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